The hottest rubber products are widely used in pha

2022-08-17
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Rubber products are widely used in pharmaceutical packaging (Part 1)

the history of using rubber in the pharmaceutical packaging industry is as old as the rubber industry. From the early rubber industry to the modern rubber industry, rubber products are widely used in medicine

rubber is used for pharmaceutical bottle stopper

1. The status of rubber bottle stopper is irreplaceable

the inherent characteristics of rubber are: high elasticity, good sealing performance and resealing performance can be obtained; Low air permeability and water permeability; Good physical and chemical properties; Sterilization resistance; The compatibility of drugs is good. These are the most important requirements of pharmaceutical packaging for bottle closures, among which butyl rubber, halogenated butyl rubber, nitrile rubber, ethylene propylene rubber, natural rubber and cis-1,4-polybutadiene rubber. This young company also plans to release RPLA - similar to PLA, it is a good material for pharmaceutical bottle closures

in order to prevent drugs from being polluted and leaking during storage, transportation and use, rubber bottle plugs are generally used as seals for pharmaceutical product packaging, such as infusion bottle plugs, lyophilizer bottle plugs, blood test tube rubber plugs, infusion pump rubber plugs, dental anesthesia needle cylinder pistons, pre installed injection needle cylinder pistons, insulin syringe pistons, and seals for various aerosol bottles (aspirators)

the correct selection of packaging materials for drug containers is an important means to ensure the quality of drugs. The materials of rubber bottle stopper, glass or plastic container may produce harmful substances, which may leak into the drug solution, causing the drug solution to precipitate, exceed the standard of particles, change the pH value, change color, etc. The ideal cork should have the following properties: low permeability to gas and water vapor; Low water absorption; Capable of needling without chip falling; It has enough elasticity and good sealing property after puncture; Good aging resistance and color stability; Resistant to steam, oxyethylene and radiation disinfection, etc

at present, there is no material that can meet the requirements of the pharmaceutical packaging industry for the combination of chemical inertia and good physical properties of its materials. Although people have improved the relevant materials in the last century, they cannot meet the ideal requirements at present

2. Rubber for making pharmaceutical corks

the requirements of drugs on corks in terms of low permeability, low extraction rate and low absorption determine that rubber corks are very demanding in the production process. People have conducted extensive research on the application of various types of rubber in pharmaceutical bottle stoppers, and achieved a series of important results

-- natural rubber is the first generation of rubber used for pharmaceutical corks. It has excellent physical properties and chip resistance, but the permeability and chemical resistance of its vulcanizate can not meet the requirements of modern pharmaceutical industry. Because natural rubber needs high content of vulcanizing agent and antioxidant to prevent aging, it will produce extractables with high residue that are not needed by drugs, and its absorption rate is not ideal. Therefore, natural rubber plugs have been included in the ranks of elimination

-- neoprene is rarely used in medicine industry, and its high permeability and high water absorption are the main reasons

-- ethylene propylene rubber is vulcanized by peroxide without any plasticizer. However, the analysis of ethylene propylene rubber corks and gaskets shows that there are often some catalyst residues from rubber, so this rubber is generally only used for corks in contact with high pH solutions or some aerosols

-- nitrile rubber has excellent heavy sealing performance, oil resistance and various solvent resistance, and is widely used in pharmaceutical propulsion rubber parts, such as metering valve of aerosol pump, oil resistant bottle stopper of veterinary medicine, etc

-- butyl rubber has high content of vulcanizing agent in the formula, long vulcanization time, low permeability, low water permeability and excellent chemical resistance. It was widely used in the production of special rubber corks by foreign pharmaceutical cork manufacturers in the 1960s. However, the production and application of chlorinated butyl rubber stopper appeared soon thereafter. In the 1970s, brominated butyl rubber with higher reactivity than butyl rubber appeared. At present, more than 90% of the world's Cork manufacturers mostly use pharmaceutical grade peelable butyl rubber or halogenated butyl rubber as raw materials for the production and manufacture of various types of pharmaceutical corks

-- butyl rubber is a copolymer of isobutene and a small amount of isoprene. With the addition of isoprene, there are double bonds on the molecular chain of butyl rubber that can be vulcanized with sulfur or other vulcanizing agents. It has low permeability to gas, high shock absorption at low frequency, excellent aging resistance, heat resistance, low temperature resistance, chemical resistance, ozone resistance, water and steam resistance, oil resistance and strong resilience. These characteristics are necessary for an ideal pharmaceutical rubber stopper, which is also the main reason why butyl rubber is widely used in the field of pharmaceutical packaging

-- halogenated butyl rubber and butyl rubber have common properties and characteristics, but due to the application capital of halogenated element chlorine waste foam granulator or the existence of bromine, the vulcanization activity and selectivity of the rubber are higher, and it is easy to co vulcanize with unsaturated rubber, eliminating the disadvantage that ordinary butyl rubber is easy to be polluted by rubber; In the vulcanization process, a variety of vulcanization systems can be selected, which can be vulcanized without sulfur or with a small amount of sulfur system, and can be vulcanized without or with a small amount of ZnO. Thus, halogenated butyl rubber is more widely used in the field of pharmaceutical packaging. Halogenated butyl rubber is the most ideal material for pharmaceutical corks due to its characteristics. In order to comprehensively improve the quality level of pharmaceutical packaging in China, the State Drug Administration decided to enforce the "butylation" of pharmaceutical rubber plugs in China by the end of 2004

the sound is as loud as 10 tons (for example, ordinary steel:

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